2018 AAOMP-IAOP Joint annual meeting
I had presented a poster at the joint meeting of American Academy of Oral & Maxillofacial Pathology (AAOMP) and International Association of Oral Pathology(IAOP) conference from June 23rd -28th, 2018 at Westin Bayshore, Vancouver, Canada. As it was a joint international conference, it was very extensive with clinico-pathologic courses as well as many oral and poster presentations.
I had presented my PhD research about the “transition of tissue inhibitor of metalloproteinase-4 to -1 expression modulates YAP/TAZ mediated aggressive phenotype in Liposarcoma”. The histological spectrum has a well-differentiated-liposarcoma(WDLS) and a more aggressive dedifferentiated-liposarcoma(DDLS). Advanced therapeutic strategies based on molecular mechanism are urgently needed, especially for DDLS. Here, I had presented my results showing high TIMP-1 expression in DDLS patients correlating with poor-prognosis, while high TIMP-4 in WDLS patients with good prognosis. I had shown that while in one hand, TIMP-1 knockdown in DDLS cells inactivated YAP/TAZ and suppressed cell-growth, migration, which was rescued by constitutively-active-form of YAP5SA. Conversely, cell-growth and migration significantly increased in TIMP-1-over-expressing-WDLS cells but suppressed by verteporfin (a YAP/TAZ inhibitor). Moreover, on the other hand, TIMP-4 knockdown in WDLS-cells activated YAP/TAZ and promoted tumorigenesis, which was inhibited by verteporfin or YAP/TAZ knockdown. Recombinant TIMP-4 showed opposite results in DDLS cells. The discussion session of my poster was very extensive, and I got many questions as well as important feed-back for my poster which I will further try to explain and elaborate in my research. This presentation has helped me to improve my research data and provide explanation to few queries which was asked during the discussion session. I will write a manuscript soon including all the important points as well.
I got awarded by the “Best oral presentation award”, known as ‘WALDRON award’ in this meeting by the AAOMP. This has been very rewarding for my hard work and it has encouraged me to work further in the field of research in molecular pathology.
Overall, participating in this conference has helped me to interact with many international researchers and update the current knowledge in diagnostic pathology as well as explore the recent developments in oral diseases and pathogenesis. This will help me progress further in my PhD course.
I would like to thank 麻豆AV and also my department and Professor Takashi Takata to giving me an opportunity and supporting me with financial assistance to present my research as it would not have been possible without their support.
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