¡¾Major Papers of the Laboratory¡¿
?Sclerostin modulates mineralization degree and stiffness profile in the fibrocartilaginous enthesis for mechanical tissue integrity, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 12, 20240604
?Tenogenic Induction From Induced Pluripotent Stem Cells Unveils the Trajectory Towards Tenocyte Differentiation, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 10, 20220309
?Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes., Sci Rep, 8, 2018
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Our department provides students with a comprehensive understanding of the basic principles of biochemistry and molecular biology.
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We are aiming at the elucidation of the molecular and cellular mechanisms underlying the formation and regeneration of cartilage, bone, teeth, tendon, and ligament. We are also investigating the roles of a clock protein, DEC, in metabolic regulation.
We are currently involved in the following research projects:
- Molecular mechanisms of tendon/ligament formation.
- Molecular mechanisms of endochondral bone formation.
- Molecular mechanisms regulating the formation and maintenance of periodontal ligaments.
- Molecular mechanisms regulating differentiation of dental pulp stem cells.
- Research on the metabolic regulation by a clock protein, DEC.
¡¾Photo explanation¡¿
Contribution of Sox9+ progenitors to axial tendon and ligament formation. A transverse section of a Sox9Cre/+;Ai14;ScxGFP embryo at E14.5 is shown. Cells of the Sox9+ lineage were detected by tdTomato reporter expression (red) and Scx+ cells were detected with anti-GFP antibody (green). Scx+ cells of the Sox9+ lineage (yellow) are distributed in and around the junction between cartilage and tendon/ligament.