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Human Behavior Science of Occupational Therapy

Prof. ISHII Daisuke

¡¾Research Keyword¡¿
Mouse model of unilateral spatial neglect, Rat model of thalamic hemorrhage, Behavioral experiment, Somatosensory, Electrophysiology, Somatosensory evoked potential (SEP), Fear memory

¡¾Recent highlights¡¿
The current project aims to explore novel approaches to promote recovery from functional impairments caused by stroke. We are currently conducting two main studies. The first involves investigating potential therapeutic compounds that enhance recovery from unilateral spatial neglect using a mouse model we have established. The second aims to facilitate sensory recovery following stroke, by examining plastic changes in somatosensory function and developing intervention strategies in both animal models and human subjects. These studies are expected to contribute to a deeper understanding of recovery mechanisms after stroke and to the development of innovative, clinically applicable rehabilitation methods.

¡¾Major Papers of the Laboratory¡¿
?Role of the medial agranular cortex in unilateral spatial neglect, Experimental Brain Research, 242, 1421-1428, 2024
?Contralateral and Ipsilateral Interactions in the Somatosensory Pathway in Healthy Humans, Frontiers in Systems Neuroscience, 15, 698758, 2021
?Ipsilesional spatial bias after a focal cerebral infarction in the medial agranular cortex: A mouse model of unilateral spatial neglect, 401, 113097, 2021
?Enhancement of acoustic prepulse inhibition by contextual fear conditioning in mice is maintained even after contextual fear extinction, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34, 183-188, 2010

¡¾·¡»å³Ü³¦²¹³Ù¾±´Ç²Ô¡¿
£¼Undergraduate Education£¾
Students learn about the fundamental physical functions necessary for daily life and methods for their assessment through lectures and practical training. In addition, they study the cognitive processes underlying human behavior, as well as behavioral change, which plays an important role in rehabilitation.

£¼Graduate Education£¾
I conduct educational and research activities with the aim of cultivating the ability to address clinical and research challenges by applying knowledge from cognitive neuroscience and scientific methodologies.

¡¾¸é±ð²õ±ð²¹°ù³¦³ó¡¿
1. Elucidation of the pathology of unilateral spatial neglect and development of novel therapeutic approaches
2. Investigation of recovery mechanisms in sensory impairments and exploration of non-invasive interventions
3. Behavioral and neurophysiological studies in both animal models and human subjects


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School of Medicine

1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, Japan 734-8553
TEL: +81-82-257-1705