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¡¾Research Keyword¡¿
Tumor Pathology, Stromal Pathology, Cancer-Associated Fibroblasts, Comprehensive Genomic and Transcriptomic Analysis, Gastrointestinal Cancer, Development of Novel Diagnostics and Therapeutics, Cancer Stem Cells, Genome Editing
¡¾Recent highlights¡¿
Pathology is an integrated medical science that investigates the causes and mechanisms of diseases. In the Molecular Pathology Laboratory, we perform advanced, exploratory, and applied pathological research based on disease mechanisms across various organs. Additionally, we practice pathological diagnosis and are committed to training specialized pathologists.
Our molecular pathological research has contributed to the identification of new diagnostic and therapeutic targets, including uncovering the role of Kinesin gene groups as novel cancer stem cell markers in cancer development. Recently, we have been actively involved not only in genome and transcriptome analyses but also leveraging traditional immunohistochemical methods to study the cancer-stroma interface. Notably, we have reported that CD109, identified as a cancer-promoting factor highly expressed in squamous cell carcinoma, is involved in brain tumors, lung adenocarcinoma, pancreatic cancer, and osteosarcoma. For instance, CD109 has been shown to promote stromal invasion in lung cancer. Based on these findings, we continue to research tumor progression mechanisms and their impact on maintaining biological homeostasis.
