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¡¾Major Papers of the Laboratory¡¿
?Rad51 accumulation at sites of DNA damage and in postreplicative chromatin., J. Cell Biol., 150(2), 283-291, 20000701

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We teach molecular biology in medical school, and molecular cell biology, biochemistry and radiation biology in graduate school.

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The goal of our department is to clarify the mechanism underlying the formation of chromosomal abnormalities induced by various types of genomic stress, especially ionizing radiation. For this purpose, we are studying the dynamic organization of nuclear functions in response to DNA damages, such as DNA double strand breaks (DSBs). We have already established the UVA laser microirradiation system to induce DSBs in a restricted nuclear region. We are now studying the dynamics of DNA repair proteins and reorganization of chromatin in response to DNA damage induced by ionizing irradiation or UVA-microirradiation using the live imaging system and the multicolor immunofluorescence technique. Molecular mechanisms underling the formation of chromosome abnormalities and DNA damage induced nuclear foci are most important topics in our lab.