Âé¶¹AV

Biological Endodontics

Prof. SHIBA Hideki

¡¾Research Keyword¡¿
Biological endodontics, Biological regeneration, Dentin/pulp complex, Dentin sialophosphoprotein, Pulp cells, Mesenchymal stem cells, Antimicrobial peptide

¡¾Recent highlights¡¿
In January, 2015, Professor Shiba succeeded the former Professor. At the same time the name of the department has been changed to ¡°Biological Endodontics¡±. The pursuit in this department is to establish a new treatment for endodontic diseases by removal of bacteria and regulation of host cell function.

¡¾Major Papers of the Laboratory¡¿
?Expression of osteoprotegerin (osteoclastogenesis inhibitory factor) in cultures of human dental mesenchymal cells and epithelial cells, J. Bone Miner. Res., 14(9), 1486-1492, 19990901
?Irsogladine maleate influences the response of gap junctional intercellular communication and IL-8 of human gingival epithelial cells following periodontopathogenic bacterial challenge., Biochem. Biophys. Res. Commun., 333, 502-507, 20050401
?Brain-derived neurotrophic factor enhances periodontal tissue regeneration:, Tissue eng., 11(9-10), 1619-1630, 20051101

¡¾·¡»å³Ü³¦²¹³Ù¾±´Ç²Ô¡¿
Undergraduate lectures in Endodontology and Operative Dentistry (School of Dentistry)
Lectures in Endodontology (Graduate School)

¡¾¸é±ð²õ±ð²¹°ù³¦³ó¡¿
1. Studies on biological regeneration of dentin/pulp complex and periapical tissues
2. Studies on biological obturation of root canals at apical areas
3. Relationship between HIV infection and dental caries
4. Development of new therapeutic agent for intractable pain
5. Development of new laboratory tests for diagnosis of dental diseases


up