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¡¾Major Papers of the Laboratory¡¿
?Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation, NATURE COMMUNICATIONS, 3, 967, 20120724
?Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis., NATURE CELL BIOLOGY, 11(10), 1197-1204, 20091201
 ?OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes, NATURE CELL BIOLOGY, 7(2), 186-194, 20050201

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(Faculty of Medicine) We take charge of lectures and experimental practices in the 2nd year. The goal of our class is to understand biochemistry and cell biology. In experimental practices, students learn the methods of biochemical experiments which are important in the medical research they progress in future. The 4th year students join laboratory works for 4 months to experience cutting edge researches. In the end of period, students present their research.

(Graduate school) Students independently progress their project discussing with a principal investigator. We aim to bring up outstanding researchers who can take an active part in worldwide basic medical research field. Therefore, we emphasize the suggestion by students based on research results and their logical thinking. In addition, we proactively give students opportunities to present their research in the conference of Japan or USA.

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The endoplasmic reticulum (ER) is a central cellular organelle that is responsible for synthesis, folding, and modification of secretory and transmembrane proteins. Various genetic and environmental insults lead to the accumulation of unfolded or misfolded proteins in the ER lumen. These conditions, collectively termed ER stress, have the potential to induce cellular damage and cell death. Cells are equipped with a system, known as the unfolded protein response (UPR), that prevents the cellular damage and death induced by ER stress. We investigate the detailed signaling pathway and activation mechanisms of UPR, and how the failure of UPR causes various diseases such as neurodegenerative diseases, cancers, and metabolic diseases.