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¡¾Research Keyword¡¿
mutagenesis, carcinogenesis, DNA damage, DNA repair, gene therapy, gene correction, genome editing, iPS cells
¡¾Recent highlights¡¿
We recently found induction of ¡°action-at-a-distance mutations¡± by a damaged base. Moreover, we established a visualization system for damaged nucleotides and found a novel factor for promoted gene correction.
¡¾Major Papers of the Laboratory¡¿
?Paradoxical role of the major DNA repair protein, OGG1, in action-at-a-distance mutation induction by 8-oxo-7,8-dihydroguanine, DNA REPAIR, 111, 202203
?Positive Feedback System Provides Efficient and Persistent Transgene Expression, MOLECULAR PHARMACEUTICS, 7(4), 1125-1132, 2010
?Effects of base excision repair proteins on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine, DNA REPAIR, 9(5), 542-550, 2010
¡¾·¡»å³Ü³¦²¹³Ù¾±´Ç²Ô¡¿
(For undergraduates) Quantitative analysis using chemical reactions (volumetric analysis); instrumental analysis; analyses of medicines.
(For graduate students) Overview of nucleic acids; mechanisms of high fidelity DNA replication; nucleic acid medicines.
¡¾¸é±ð²õ±ð²¹°ù³¦³ó¡¿
£±£®Mutagenesis and carcinogenesis induced by DNA damage.
£²£®Suppression of mutagenesis by DNA repair.
£³£®Gene therapy by gene correction (genome editing).
£´£®Mutations and genome stability in iPS cells.
£µ£®Visualization system for damaged nucleotides.
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