なぜ一部の人々は他の人々よりも特定の疾患(例:心臓病)を発症しやすいのでしょうか?その答えは彼らのゲノムにあります。私たちは个人间の遗伝的変异が异なる细胞タイプでの遗伝子発现に与える影响を研究し、ゲノムと疾患の间の欠けているつながりを理解することを目指しています。
Why are some people more likely to develop certain diseases( e.g. heart disease) than the others? The answer lies in their genomes. We study the effects of genetic variations between individuals on gene expression in different cell-types, aiming to understand missing links between our genomes and diseases.
办别测飞辞谤诲蝉:single-cell genomics, genetics, transcriptomics, bioinformatics
- An atlas of human long non-coding RNAs with accurate 5' ends. Nature 543(7644), 199-204(2017)
- Recombination of repeat elements generates somatic complexity in human genome. Cell S0092-8674(22)00784-X (2022)
- C1 CAGE detects transcription start sites and enhancer activity at single-cell resolution. Nat Comm 10, 360(2019)