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Microbiology

Prof. KURODA Teruo

¡¾Research Keyword¡¿
Multidrug resistance, Antiseptic resistance, Biosynthesis of antibiotics, Microbial useful enzymes for the industrial application

¡¾Recent highlights¡¿
In 2015, we identified the target of 6,6¡¯-dihydroxythiobinupharidine in Staphylococcus aureus. Also, we reported about the construction of higher production system for antituberculous drug in Escherichia coli. In 2016, we reported about a novel factor for antiseptic resistance in Serratia marcescens.

¡¾Major Papers of the Laboratory¡¿
?Effects of the order of exposure to antimicrobials on the incidence of multidrug-resistant Pseudomonas aeruginosa, Scientific Reports, 13(1), 8826, 20230531
?Whole-Genome and Plasmid Comparative Analysis of Campylobacter jejuni from Human Patients in Toyama, Japan, from 2015 to 2019, Microbiology Spectrum, 11(1), e02659-22, 20230109
?Comprehensive analysis of resistance-nodulation-cell division superfamily (RND) efflux pumps from Serratia marcescens, Db10, Scientific reports, 9(1), 4854, 20190319

¡¾·¡»å³Ü³¦²¹³Ù¾±´Ç²Ô¡¿
?Microbiology£ºMicroorganisms (bacteria, viruses, fungi) which cause infectious diseases
?Biochemistry I£ºDNA replication, Transcription, Translation
?Biochemistry II£ºProtein and amino acids
?Antibiotics and Drug resistance: Action mechanism of antimicrobial agents
?Genetic Engineering£ºTechnique of gene manipulation
?Experiments of Microbial Chemistry£ºFundamental Technique for Microbiology

¡¾¸é±ð²õ±ð²¹°ù³¦³ó¡¿
£±£®Screening of seed compounds which has antimicrobial activity and Identification of its action target
£²£®Study of antiseptic resistance mechanism
£³£®Study of emergence of multidrug resistant bacteria
£´£®Study of tolerance for Na+ in marine bacteria
£µ£®Structural study of microbial useful enzymes for the industrial application and target proteins for the drug development
£¶£®Functional analysis of antibiotic biosynthetic genes from actinomycetes and its application for the production of useful compounds

¡¾Figure explanation¡¿ Action mechanism of 6,6¡¯-dihydroxythiobinupharidine in Staphylococcus aureus

¡¾Figure explanation¡¿ Action mechanism of riccardin C derivatives in Staphylococcus aureus


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